What do these products do in this instrument?
Multiport Rotary Valves: Formulation and Refill-Source Selection
In selector-valve configurations, connect the current medium or maintenance path with priming and feed control. Specify destinations for old formulation and wash liquid, then verify arrival of the new composition at the culture vessel.
MRV3 selects sources or destinations and requires a port-state diagram and shared-volume budget. Port count indicates routing options; confirm pressure in each state and independent simultaneous supply requirements separately.
Tubing pinch-off solutions: flexible-branch isolation and maintenance
Control flow in tubing-pinch feed paths, coordinated with bottle changes, maintenance and restart. Confirm sealing, tubing condition and complete cleaning or sterilization procedures for the actual system.
Discuss tubing pinch-off for the specific project. Tubing and fittings define the liquid-contact path. Validate tubing material, wall thickness, pinch seal and replacement procedure together, and assess cleaning or sterilization across the complete path.
Define connections using the instrument's port-state diagram
This page covers multiport rotary valves and tubing pinch-off solutions. Identify every port, current source, receiving destination and branch requiring isolation. Check connectivity during aspiration, delivery, washing, maintenance and power loss. Valve selection actions must correspond to permitted drive conditions.
Include renewal of shared segments after switching in the sequence
After source switching, shared tubing may retain the previous composition. Record volume and arrival delay from the new source to the receiver, and measure residue and recovery for the actual worst-case switching combination. Confirm port positioning and arrival of new liquid separately.
Translate actual branch conditions into configuration requirements
| Condition | To confirm |
|---|---|
| Connections and pressure | Provide port diagrams and pressure conditions for all operating, cleaning and shutdown states. |
| Shared volume | Identify residue locations after source changes, flushing volumes and discharge destinations. |
| Control and isolation | Check valve-position feedback, pump actions, shutoff leakage and permitted power-off states. |
| Operation | Specific operating conditions |
|---|---|
| Medium switching | All ports, valve states, pressures in each state, shared volume and flushing volume |
Compare product configurations by the roles on this page
| Product | Configuration option | Conditions to verify |
|---|---|---|
| MRV3 multiport rotary valve | Multiple-source selection | Compare 10-, 16- and 24-port options and port diagrams; verify high-pressure suitability separately |
Explore specific operating and validation tasks
Medium switching
Bottle changes, priming and switching are different events. Calculate shared volume, then verify arrival time and initial composition to prevent cleaning residue entering the culture.
Confirm product roles in actual operation
| Operation | Measurements and observations | Priority checks |
|---|---|---|
| Medium switching | Check unintended connections, leakage, backflow and post-switching residue in each state; measure flushing volume and arrival delay through the complete path | Misalignment, shared-segment residue or abnormal switching pressure may affect the next task |
Record output across the run, replenishment interruptions, first flow after bottle changes and reactor volume balance.
Do more valve ports mean more channels can supply liquid simultaneously?
Check port connection structure and drive configuration. The number of selectable sources, independent paths and simultaneous-operation capability are different conditions, determined by actual connections in each state.
Refilling or resetting a single syringe can interrupt supply. Continuous-operation capability and aseptic isolation both require system validation.