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Home/Applications/Synthetic biology/Continuous feeding
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Valveless Metering Pumps for Continuous Feeding

Application guide

Explore valveless metering-pump placement, coordination and configuration for suitable extended feeding, with links to operating and validation tasks.

Application guides

Continuous feeding application guide

Continuous feeding fluidics overview
Syringe pumps in continuous feeding
Valveless Metering Pumps for Continuous Feeding
Supply mode
Fluidic valves in continuous feeding
Medium switching
Bubble and pressure sensing in continuous feeding
Fluidic Connections and Protection for Continuous Feeding
Flow-path protection

ON THIS PAGE

What do these products do in this instrument?Distinguish repeated dosing from continuous supply firstHandle starts/stops, replenishment and two-stream merging separatelyTranslate actual branch conditions into configuration requirementsCompare product configurations by the roles on this pageExplore specific operating and validation tasksConfirm product roles in actual operationCan the same configuration be retained after changing the target dose or time window?ReferencesRelated guides

01What do these products do in this instrument?

Valveless metering pumps: suitable long-duration feed metering

Provide continuous or repeated feed output within actual formulation, speed and backpressure limits, coordinated with process stages and source vessels. Measure time-window flow and cumulative volume across operation, bottle changes, stopping and restart.

Compare RPL-series options for repeated metering or auxiliary continuous supply according to the task. Confirm individual dose, flow over the operating time window and cumulative volume separately. For proportioning, also compare the liquid actually arriving from each of the two paths.

02Distinguish repeated dosing from continuous supply first

Compare valveless metering pumps for repeated dosing or auxiliary continuous supply in suitable configurations. Repeated dosing requires assessment of individual deliveries and liquid released after stopping; continuous tasks require time-window flow and cumulative volume. After converting the rotation program to a set volume, measure the actual received volume under the installed flow-path and load conditions.

03Handle starts/stops, replenishment and two-stream merging separately

Starting, stopping and bottle changes affect actual arrival. Record initial liquid delivery, recovery delay and terminal drips. For two-stream proportioning, check each path's load and arrival time before checking the composition and mixing after the junction. A matching cumulative ratio does not replace composition validation during startup and within each operating time window.

04Translate actual branch conditions into configuration requirements

Valveless metering-pump configuration for continuous feeding
ConditionTo confirm
Output requirementsDefine individual dose or target flow, duration, cumulative volume and allowable interruptions.
Installed loadSpecify medium, inlet conditions, outlet backpressure and downstream connections.
Start-stop behavior and proportioningMeasure initial, steady-state and restart output. For two-stream tasks, also check actual arrival and mixing results.
Operations supported in this instrument
OperationSpecific operating conditions
Supply modeActual flow, cumulative volume, allowable interruptions, backpressure, refills and operating duration

05Compare product configurations by the roles on this page

Configuration options for the product roles on this page
ProductConfiguration optionConditions to verify
RPL Valveless Metering PumpSuitable repeated or continuous meteringCompare displacement, speed, actual backpressure and starts/stops; check two-stream ratios separately
  • RPL Valveless Metering Pump

06Explore specific operating and validation tasks

Supply mode

Measure cycle output and pauses under actual load. Correct cumulative volume does not ensure that every interval meets its flow requirement; define acceptance criteria separately.

  • Supply mode

07Confirm product roles in actual operation

Operating-point validation and fault localization
OperationMeasurements and observationsPriority checks
Supply modeMeasure operating-flow trends and cumulative volume, including refill interruptions. Evaluate proportioning, process or analytical results according to the task.An empty source, bubbles, slip, pressure changes or resetting can disturb continuous output.

Record output across the run, replenishment interruptions, first flow after bottle changes and reactor volume balance.

08Can the same configuration be retained after changing the target dose or time window?

Validate starts/stops, operating increments and receiver-end drips under the new actual load. Measure repeated dispensing dose by dose; for continuous supply, measure output within operating time windows and cumulatively. Then determine whether the existing configuration and program still meet requirements.

Refilling or resetting a single syringe can interrupt supply. Continuous-operation capability and aseptic isolation both require system validation.

References

View references (1)
  1. [1]FOREACH RPL valveless metering pumps: configurations and specifications

Related guides

  • Back to the continuous feeding fluidics overview
  • Supply mode

Related Products

RPL Valveless Metering Pump; representative configuration. Select capacity, materials and interfaces for the application.

RPL Valveless Metering Pump

Related Technical Articles

What Is a Valveless Metering Pump? Working Principle, Applications and Selection

A valveless metering pump is a positive-displacement pump that combines rotary and axial reciprocating piston motion to switch the fluid path, draw liquid in and discharge it. Its pumping mechanism does not rely on conventional inlet and outlet check valves. It can serve reagent dispensing, titration, filling and two-fluid proportional delivery, but metering performance still has to be verified with the actual fluid, pressure, tubing, drive and cleaning conditions.

2026-09-21View Details

Valveless Metering Pump Selection Guide: FOREACH Models and Applications

To select a valveless metering pump, first define the volume per dose and the time available for dispensing. Then check displacement per revolution, drive speed, wetted materials, backpressure and connections, and verify delivery in the actual fluid path. Neither flow rate alone nor the label ‘metering pump’ is enough to select a model.

2026-09-16View Details

Discuss fluidic configurations for continuous feeding

Provide a fluidic diagram, actual liquids and pressures in each operating state. Compare displacement, speed, actual backpressure and start-stop behavior; verify dual-stream ratios separately. Assess suitable configurations against this guide's validation objectives.

Contact an engineer