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Home/Applications/Life science/Process feeding and sampling
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Bubble and pressure sensing in process feeding and sampling

Application guide

This page explains the location, coordination and configuration requirements of bubble and pressure detection for relating fluid-path anomalies to process records through instrument control, with links to relevant operating and validation tasks.

Application guides

Process feeding and sampling application guide

Fluidic Overview for Process Feeding and Sampling
Syringe pumps in process feeding and sampling
Online sampling
Valveless metering pumps in process feeding and sampling
Feeding
Fluidic Valves for Process Feeding and Sampling
Bubble and pressure sensing in process feeding and sampling
Tubing and fittings in process feeding and sampling

ON THIS PAGE

What do these products do in this instrument?Match sensing locations to specific fluidic problemsConnect signals, action windows and recovery conditionsTranslate actual branch conditions into configuration requirementsCompare product configurations by the roles on this pageConfirm product roles in actual operationCan dispensing be repeated immediately after bubbles or abnormal pressure are detected?ReferencesRelated guides

01What do these products do in this instrument?

Bubble and pressure sensing: signals for process event logging

Provide pressure and bubble signals at specified feeding or sampling locations. The controller can associate them with abnormal process stages. Confirm actual cumulative volume, sample representativeness and process results separately.

ABD provides bubble or liquid-state signals for defined tubing; PDM5 provides pressure information at a defined location. Configure module, position and action window separately; the controller associates affected samples or tasks.

02Match sensing locations to specific fluidic problems

Bubble modules report bubble or liquid state in defined tube segments; pressure modules report pressure at defined positions. Before selecting mounting points, define the phase and abnormality to observe: aspiration, delivery, source depletion or branch-load changes. Associate sensor positions with affected samples, cuvettes or stations.

03Connect signals, action windows and recovery conditions

The same signal may mean different things at different valve positions or operating phases. Record normal ranges and faults with actual liquids, tubing and sequences. The controller combines action timing, confirmed delivery status, volume records and sample identity to pause, review or recover; one pressure change cannot directly identify a blockage location or specific cause. Distinguish measured, estimated and unknown volumes; completion of a command does not prove actual liquid delivery.

04Translate actual branch conditions into configuration requirements

Bubble and pressure detection configuration requirements for process feeding and sampling
ConditionTo confirm
Installation conditionsSpecify tubing dimensions, liquid, sensing location and branch to observe.
Timing and baselineRecord valve positions, pump actions, normal changes and fault-detection windows.
Abnormality handlingAssociate affected containers with confirmed delivery status and volume records; define conditions for review, continuation or re-execution. Distinguish measured, estimated and unknown volumes; completion of a command does not prove actual liquid delivery.

05Compare product configurations by the roles on this page

Configuration options for the product roles on this page
ProductConfiguration optionConditions to verify
ABD bubble-detection moduleBubble or liquid-state identification in defined tubingValidate detection and false alarms for tubing material, dimensions, medium and action window
PDM5 pressure-detection modulePressure-state monitoring at a defined fluidic locationConfirm range and wetted configuration by model; validate normal baseline and abnormalities separately
  • ABD bubble-detection module
  • PDM5 pressure-detection module

06Confirm product roles in actual operation

Connect the culture process, actual feeding and sample analysis, retaining records across the entire run.

07Can dispensing be repeated immediately after bubbles or abnormal pressure are detected?

First establish whether partial delivery has occurred and which container is affected. Immediate repetition may double-dose it. Act on the actual state and recheck the first cycle after recovery.

Periodic dispensing, continuous feeding and aseptic sampling have different requirements. A single metering test cannot establish all three.

References

View references (2)
  1. [1]FOREACH ABD bubble-detection module: configurations and specifications
  2. [2]FOREACH PDM5 pressure-detection module: configurations and specifications

Related guides

  • Back to the process feeding and sampling fluidics overview

Related Products

ABD bubble-detection module; representative configuration. Select capacity, materials and interfaces for the application.

ABD bubble-detection module

PDM5 pressure-detection module; representative configuration. Select capacity, materials and interfaces for the application.

PDM5 pressure-detection module

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What is flow resistance calculation for? Using the Foreach calculator in fluid-path design and selection

The free flow rate of the pump meets the requirements. After installing the pipelines, valves and joints, the liquid supply at the end is insufficient. Flow resistance calculations can break the problem down into comparable data: what pressure differential is required at the target flow rate, where does the pressure loss mainly occur, and what happens if the pipe diameter, pipe length, component Cv or medium viscosity is changed. This article combines the actual function of the Foreach flow resistance calculator with a recalculable fluid circuit case to explain how to use the calculation results for design, selection, troubleshooting and prototype verification.

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Valveless Metering Pump Selection Guide: FOREACH Models and Applications

To select a valveless metering pump, first define the volume per dose and the time available for dispensing. Then check displacement per revolution, drive speed, wetted materials, backpressure and connections, and verify delivery in the actual fluid path. Neither flow rate alone nor the label ‘metering pump’ is enough to select a model.

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Discuss fluidic configurations for life science processes

Provide a fluid-path diagram, actual liquids and pressures in each state. Validate detection and false alarms for the tubing, dimensions, media and action window. Confirm range and wetted configuration by model, then test normal baselines and faults separately against the guide's validation objectives.

Contact an engineer