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Home/Applications/Synthetic biology/Bioprocess Integration
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Diaphragm pumps in bioprocess integration

Application guide

This page explains the diaphragm pump's position, supporting components and configuration requirements for suitable waste and gas-containing aspiration in bioprocess systems, with links to operating and validation tasks.

Application guides

Bioprocess Integration Guide

Bioprocess integration fluidics overview
Syringe pumps in bioprocess integration
Valveless Metering Pumps for Bioprocess Integration
Diaphragm pumps in bioprocess integration
Fluidic valves in bioprocess integration
Paths and interlocks
Bubble and Pressure Monitoring for Bioprocess Integration
Tubing and fittings in bioprocess integration

ON THIS PAGE

What do these products do in this instrument?First identify the actual connection architecture for gas-containing aspirationCombine suction/drainage and vessel protection into a complete cycleTranslate actual branch conditions into configuration requirementsCompare product configurations by the roles on this pageConfirm product roles in actual operationCan an air-containing aspiration pump be selected from liquid-flow requirements alone?ReferencesRelated guides

01What do these products do in this instrument?

Gas-Liquid Diaphragm Pumps: Suitable Waste and Gas-Containing Aspiration

Serve waste removal in actual air-containing inlet or vessel-vacuum architectures, accounting for biomass condition, foam and waste bottles. Include full-vessel, blockage and post-maintenance sealing checks in system interlocks.

DPGL800 handles gas or gas–liquid aspiration permitted by its specific configuration. Check inlet gas content, foam, peak inflow and container vacuum; use a separately suitable solution for continuous liquid-only transfer.

02First identify the actual connection architecture for gas-containing aspiration

During direct aspiration, the permitted gas-liquid mixture passes through the pump. In vacuum-over-liquid collection, liquid enters a waste vessel and the pump connects to its gas space. Confirm inlet media, biomass or foam, vacuum and discharge destination for the configuration.

03Combine suction/drainage and vessel protection into a complete cycle

Check actual drainage against peak inflow, allowable accumulation and the available aspiration window. Test interlocks for full vessels, foam, leaks and blockage. After maintenance, verify sealing and isolation before continuing. Select separate suitable configurations for continuous liquid-only transfer and wash supply.

04Translate actual branch conditions into configuration requirements

Diaphragm-pump configuration requirements for bioprocess integration
ConditionTo confirm
Inlet mediumDistinguish liquid-only flow, intermittent gas entrainment and foam, and confirm the aspiration modes permitted by the configuration.
Tubing and containersProvide suction lift, outlet load, tubing and waste-container conditions.
Actual supply and removalMeasure incoming liquid, residue and emptying at the station; check handling after full level, shortage or blockage.

05Compare product configurations by the roles on this page

Configuration options for the product roles on this page
ProductConfiguration optionConditions to verify
DPGL800 gas–liquid diaphragm pumpSuitable gas–liquid aspiration or container-vacuum branchesConfirm inlet medium and waste architecture; not for continuous liquid-only transfer (100% liquid)
  • DPGL800 gas–liquid diaphragm pump

06Confirm product roles in actual operation

Include extended operation, power loss, depleted feed, blockage and post-maintenance restart. Check cumulative delivery and contamination boundaries.

07Can an air-containing aspiration pump be selected from liquid-flow requirements alone?

Check the specific configuration against actual inlet phase, vacuum and operating period, then measure installed drainage and container conditions. Gas or gas-liquid aspiration specifications do not establish continuous liquid-only transfer capability.

Evaluate fluidic feedback and biological process results separately. A component combination alone does not establish sterility or continuous-culture capability.

References

View references (1)
  1. [1]FOREACH DPGL800 gas–liquid diaphragm pump: configurations and specifications

Related guides

  • Return to the bioprocess integration overview

Related Products

DPGL800 gas–liquid diaphragm pump; representative configuration. Select capacity, materials and interfaces for the application.

DPGL800 gas–liquid diaphragm pump

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Discuss fluidic configurations for bioprocess integration

Provide a fluidic diagram, actual liquids and pressures in each operating state. Identify the inlet medium and waste-removal architecture; the gas-liquid option is not for continuous transfer of 100% liquid. Compare configurations against this guide's validation objectives.

Contact an engineer