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Home/Applications/Laboratory automation/Sample preparation platforms
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Air-displacement pipetting pumps in sample preparation platforms

Application guide

Explore air-displacement pipetting-pump placement, coordination and configuration for tip-based sample preparation, with links to operating and validation tasks.

Application guides

Sample preparation platform application guide

Sample preparation platform fluidics overview
Syringe pumps in sample preparation platforms
Air-displacement pipetting pumps in sample preparation platforms
Disposable-tip sample transfer
Diaphragm pumps in sample preparation platforms
Washing and product recovery
Multiport rotary valves in sample preparation platforms
Path scheduling
Bubble and pressure detection in sample preparation platforms
Tubing and fittings in sample preparation platforms

ON THIS PAGE

What do these products do in this instrument?Coordinate air-displacement drive with tips and motionDevelop pipetting sequences for actual liquids and receiving actionsTranslate actual branch conditions into configuration requirementsCompare product configurations by the roles on this pageExplore specific operating and validation tasksConfirm product roles in actual operationDoes completed pump movement confirm that the target well received the specified volume?ReferencesRelated guides

01What do these products do in this instrument?

Air-displacement pipetting pumps: tip-based sample preparation

Provide aspiration and dispensing drive at disposable-tip stations, coordinated with liquid type, robot motion and sample vessels. Configure transfer, dilution and separation actions for what each step must retain.

SMTP serves disposable-tip air-displacement architectures, with the pump displacing an air column. Tip sealing, liquid type, immersion position and platform motion jointly determine received volume.

02Coordinate air-displacement drive with tips and motion

Air-displacement pipetting pumps move liquid in tips through air-column displacement. Sealing after pickup, tip specification, immersion and platform motion all contribute to aspiration and dispensing. Describe tip-based operations separately from fixed wetted tubing, identifying source well, receiving well and consumable state for each step.

03Develop pipetting sequences for actual liquids and receiving actions

Match aspiration speed, waits, air gaps and dispensing mode to the specific liquid and container. Low remaining volume, foam, droplets and post-tip-change state may affect reception. Schedule tip changes according to contamination-control requirements; when discarding liquid or recovering nucleic-acid eluate, verify destination together with sample identity.

04Translate actual branch conditions into configuration requirements

Air-displacement pipetting pump configuration requirements for sample preparation platforms
ConditionTo confirm
Tips and sealingProvide tip specifications, pickup/ejection method and sealing checks after pickup.
Liquid and positionRecord liquid type, minimum remaining volume, immersion depth and receiving position.
Results by wellCheck received volume, empty wells or residual liquid, and tip-change and well records.
Operations supported in this instrument
OperationSpecific operating conditions
Disposable-tip sample transferDisposable-tip specification and pickup seal, actual liquid class, source volume remaining, immersion depth, working volume and receiving position

05Compare product configurations by the roles on this page

Configuration options for the product roles on this page
ProductConfiguration optionConditions to verify
SMTP air-displacement pipetting pumpAir displacement with disposable tipsValidate tip sealing, liquid type and motion together
  • SMTP air-displacement pipetting pump

06Explore specific operating and validation tasks

Disposable-tip sample transfer

Start liquid actions only after the probe or tip reaches position. After aspiration or dispensing, check retained droplets and receiving status. Recheck these conditions when increasing workstation speed.

  • Disposable-tip sample transfer

07Confirm product roles in actual operation

Operating-point validation and fault localization
OperationMeasurements and observationsPriority checks
Disposable-tip sample transferMeasure actual receipt at the target vessel, including low source levels, tip pickup and ejection, and contamination across sample sequences. Verify sample or well identity and downstream method results.Tip leaks, aspiration of air, hanging droplets, incorrect immersion or missed tip changes can affect delivery and contamination.

Validate working volume, timing across workstations, sample identity and the first operation after restart together.

08Does completed pump movement confirm that the target well received the specified volume?

Also check tip sealing, air aspiration, well position and dispensing state, and measure actual reception. The drive-complete signal can assess the operation only together with these records.

Successful platform operation does not replace assessment of nucleic acid, cell or analytical method results.

References

View references (1)
  1. [1]FOREACH SMTP air-displacement pipetting pump: configurations and specifications

Related guides

  • Return to the sample preparation workstation overview
  • Disposable-tip sample transfer

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SMTP air-displacement pipetting pump; representative configuration. Select capacity, materials and interfaces for the application.

SMTP air-displacement pipetting pump

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What is a programmable automatic air-displacement pipetting pump?

A programmable automatic air-displacement pipetting pump is a liquid-handling component whose aspiration, dispense, speeds and sequence are set through control commands. This article focuses on air-displacement modules that use disposable tips in OEM instruments, with FOREACH SMTP2 as an example of operation, monitoring and selection limits.

2026-09-28View Details

What Is Pipetting? Manual and Automated Workflows Compared

Pipetting is the transfer of a specified volume of liquid from one location to another. Examples include moving 100 µL from a sample tube into a reaction vessel, or adding sample and diluent in a defined ratio.

2026-09-29View Details

Discuss fluidic configurations for your sample preparation workstation

Provide a fluid diagram, the actual liquids and pressures in each state. Tip sealing, liquid type and motion require joint validation. Compare suitable configurations against the validation objectives described here.

Contact an engineer