What do these products do in this instrument?
Multiport rotary valves: sampling, renewal and receiving-destination selection
In selector-valve sampling paths, connect the process source, analytical interface or discard outlet in coordination with the pump. Define current source and sample time, and include shared-path flushing in the sampling budget.
MRV3 selects sources or destinations and requires a port-state diagram and shared-volume budget. Port count indicates routing options; confirm pressure in each state and independent simultaneous supply requirements separately.
Pinch-valve arrangements: sampling-tube isolation
Control sampling or maintenance flow in the actual flexible branch, coordinated with the sampling port and fittings. Include pinch sealing, assembly and replacement procedures in contamination-boundary assessment.
Discuss tubing pinch-off for the specific project. Tubing and fittings define the liquid-contact path. Validate tubing material, wall thickness, pinch seal and replacement procedure together, and assess cleaning or sterilization across the complete path.
Define connections using the instrument's port-state diagram
This page covers multiport rotary valves and tubing pinch-off solutions. Identify every port, current source, receiving destination and branch requiring isolation. Check connectivity during aspiration, delivery, washing, maintenance and power loss. Valve selection actions must correspond to permitted drive conditions.
Include renewal of shared segments after switching in the sequence
After source switching, shared tubing may retain the previous composition. Record volume and arrival delay from the new source to the receiver, and measure residue and recovery for the actual worst-case switching combination. Confirm port positioning and arrival of new liquid separately.
Translate actual branch conditions into configuration requirements
| Condition | To confirm |
|---|---|
| Connections and pressure | Provide port diagrams and pressure conditions for all operating, cleaning and shutdown states. |
| Shared volume | Identify residue locations after source changes, flushing volumes and discharge destinations. |
| Control and isolation | Check valve-position feedback, pump actions, shutoff leakage and permitted power-off states. |
| Operation | Specific operating conditions |
|---|---|
| Flexible-tube control | Tubing material, OD/wall thickness, pressure/vacuum, pinch-off and cycle count |
Compare product configurations by the roles on this page
| Product | Configuration option | Conditions to verify |
|---|---|---|
| MRV3 multiport rotary valve | Multiple-source selection | Compare 10-, 16- and 24-port options and port diagrams; verify high-pressure suitability separately |
Explore specific operating and validation tasks
Flexible-tube control
Pinching reduces liquid contact with the valve body, but tubing, fittings and maintenance remain within the contamination-control boundary. After installation, check closure, sealing and cleaning or sterilization procedures.
Confirm product roles in actual operation
| Operation | Measurements and observations | Priority checks |
|---|---|---|
| Flexible-tube control | Measure closed-state leakage, open-state resistance and tubing condition after cycling. Check complete-path sealing and contamination-control boundaries after maintenance. | Tube fatigue, incorrect installation or differential pressure outside configuration limits may prevent closure |
Compare process and collected samples, checking target retention, contamination and reactor-volume changes.
Do more valve ports mean more channels can supply liquid simultaneously?
Check port connection structure and drive configuration. The number of selectable sources, independent paths and simultaneous-operation capability are different conditions, determined by actual connections in each state.
Removing cell aggregates may change the measured target. Reduced valve-body contact through a pinch valve does not make the entire path sterile.