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Home/Applications/In Vitro Diagnostics/Clinical chemistry analyzer
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Bubble and pressure detection in clinical chemistry analyzers

Application guide

A bubble alarm during sample aspiration and a pressure change during reagent dispensing affect different parts of a clinical chemistry cycle. Choose the monitored branch and observation window around the sample, reagent or wash operation, then define how the controller identifies the affected reaction cuvette.

Application guide

Clinical chemistry analyzer

Clinical chemistry analyzer
Diaphragm pumps in clinical chemistry analyzers
Probe/cuvette wash supply and waste removal
Bubble and pressure detection in clinical chemistry analyzers
Tubing and fittings in clinical chemistry analyzers
Multiport rotary valves in clinical chemistry analyzers
Sample, reagent and wash-path switching
Piston pumps in clinical chemistry analyzers
Metered reagent dispensingSample aspiration and transfer
Sampling and wash probes in clinical chemistry analyzers
Syringe pumps in clinical chemistry analyzers

On this page

What do these products do in this instrument?Choose the branch before choosing the alarm windowKeep a fluid-path alarm separate from a confirmed doseTranslate actual branch conditions into configuration requirementsState monitoringCompare product configurations by the roles on this pageRelated operations and architecture comparisonsConfirm product roles in actual operationCan a common reagent-supply sensor identify a faulty cuvette?ReferencesRelated guides

01What do these products do in this instrument?

Bubble and pressure sensing: identify air aspiration, bubbles and abnormal pressure

Monitor the actual sample, reagent or wash branch at a location where its state can be interpreted. A sensor upstream of a selector describes the selected supply; it does not independently identify which downstream cuvette received liquid. That association comes from the analyzer sequence and its delivery records.

ABD provides bubble or liquid-state signals for defined tubing; PDM5 provides pressure information at a defined location. Configure module, position and action window separately; the controller associates affected samples or tasks.

02Choose the branch before choosing the alarm window

For sample aspiration, relate the sensing position to the probe and any intentional air segment. For a reagent supply, decide whether the purpose is to observe bottle depletion before the metering unit or disturbances during delivery. A common supply sensor covers a different part of the path from a sensor on one metering branch; map the intervening valves before assigning an alarm to a sample.

Further technical reading

  • Why Do Air Bubbles Delay or Bias Piston Pump Dispensing?
  • What is flow resistance calculation for? Using the Foreach calculator in fluid-path design and selection

03Keep a fluid-path alarm separate from a confirmed dose

Record the selected source, valve state and cuvette when the event occurs. Distinguish no delivery, partial delivery and a completed transfer using the available observations; mark an unmeasured amount as unknown. The controller can then hold the affected task for the method-defined response. Repeating the command before resolving a partial dose may change the reaction ratio.

04Translate actual branch conditions into configuration requirements

Bubble- and pressure-sensing configuration conditions in clinical chemistry analyzers
ConditionTo confirm
Sample aspirationSpecify the actual specimen or justified test medium, probe sequence, intended air segments and sensor position relative to the source and metering unit.
Reagent dispensingInclude bottle level, replenishment state and valve transitions in the baseline; compare the first dose after a bottle change with routine delivery.
Alarm associationDefine which source and cuvette records accompany the signal, how uncertain delivery is represented, and which tasks must remain paused.
Operations supported in this instrument
OperationSpecific operating conditions
State monitoringSampling or reagent branch, actual liquid and tubing, valve state, intended air segments, acquisition timing and the cuvette affected by a late signal

05State monitoring

During low-volume sample aspiration, compare an alarm with probe position, remaining specimen volume and the actual received sample. Air entry and a restriction can require different handling even when both interrupt the cycle.

During reagent replenishment, keep the source-change event separate from subsequent cuvette additions. Reprime toward the intended outlet and establish which addition was unfinished before resuming the sequence.

Test the complete response while normal valve changes and intended air segments are present. A detector that responds in isolation may still create false stops if the observation window includes an expected transition.

After a fault, verify the repaired path and first subsequent transfer separately from the disposition of the earlier reaction. A recovered sensor baseline does not determine that reaction result.

06Compare product configurations by the roles on this page

Configuration options for the product roles on this page
ProductConfiguration optionConditions to verify
ABD bubble-detection moduleBubble or liquid-state identification in defined tubingValidate detection and false alarms for tubing material, dimensions, medium and action window
PDM5 pressure-detection modulePressure-state monitoring at a defined fluidic locationConfirm range and wetted configuration by model; validate normal baseline and abnormalities separately
  • ABD bubble-detection module

    ABD bubble-detection module

    View Details
  • PDM5 pressure-detection module

    PDM5 pressure-detection module

    View Details

07Related operations and architecture comparisons

Sample aspiration and transfer

Low remaining volume, probe contact with a wall and aspiration/dispensing reversals may alter delivery. First measure error in the target container, then assess residue using a blank after a concentrated sample; one calibration cannot address both issues.

  • Sample aspiration and transfer

Metered reagent dispensing

For repeated dispensing, record usable doses per fill and replenishment points. Confirm restoration of the liquid column after replenishment before evaluating the first dose. Retrying an interrupted action must also avoid duplicate addition to the same cuvette.

  • Metered reagent dispensing

08Confirm product roles in actual operation

Operating-point validation and fault localization
OperationMeasurements and observationsPriority checks
State monitoringChallenge source depletion, a permitted introduced bubble and representative branch-load changes during the relevant phase. Record missed events, false alarms and time from signal to controller action, then measure the affected transfer at the cuvette.A normal trace after priming may coexist with an earlier incomplete dose. Separate the event that stopped the task from the evidence used to release the next sample.

Accept the monitoring arrangement only when a recorded event can be traced to the affected operation and a defined response. Check actual first-dose delivery after recovery and assess any carryover through the assay sequence.

09Can a common reagent-supply sensor identify a faulty cuvette?

It identifies the state at its sensing location. The controller must relate that event to the selected branch, elapsed transfer sequence and current cuvette; shared volume and delayed signal arrival can widen the set of operations requiring review.

The assay determines sample suitability; full-scale metering specifications cannot replace small-dose and complete-instrument results.

References

View references (2)
  1. [1]FOREACH ABD bubble-detection module: configurations and specifications
  2. [2]FOREACH PDM5 pressure-detection module: configurations and specifications

Related guides

  • Back to the clinical chemistry analyzer fluidics overview

Related Products

ABD Air-bubble detectors

ABD Air-bubble detectors

PDM5 Pressure sensors

PDM5 Pressure sensors

Related Technical Articles

Why Do Air Bubbles Delay or Bias Piston Pump Dispensing?

A completed piston stroke does not prove that the intended liquid volume reached the vessel. Bubble compression temporarily stores displacement; expansion can then cause a trailing dispense or affect the next cycle. Locate where bubbles first appear and compare synchronized pressure and individual dispense masses before and after priming.

2026-09-10View Details

What is flow resistance calculation for? Using the Foreach calculator in fluid-path design and selection

The free flow rate of the pump meets the requirements. After installing the pipelines, valves and joints, the liquid supply at the end is insufficient. Flow resistance calculations can break the problem down into comparable data: what pressure differential is required at the target flow rate, where does the pressure loss mainly occur, and what happens if the pipe diameter, pipe length, component Cv or medium viscosity is changed. This article combines the actual function of the Foreach flow resistance calculator with a recalculable fluid circuit case to explain how to use the calculation results for design, selection, troubleshooting and prototype verification.

2026-09-11View Details

Discuss Your IVD Fluidic Requirements

Share the instrument type, sample and reagent properties, working volumes, cycle timing, fluid path and acceptance criteria so we can discuss suitable components and prototype evaluation.

Discuss your application