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Home/Applications/In Vitro Diagnostics/Clinical chemistry analyzer
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Sampling and wash probes in clinical chemistry analyzers

Application guide

Focusing on container-side sampling and delivery, cleaning coverage and residual-liquid removal in clinical chemistry analyzers, this page explains sampling- and wash-probe locations, coordination and configuration conditions, linking to related operating and validation tasks.

Application guide

Clinical chemistry analyzer

Clinical chemistry analyzer
Diaphragm pumps in clinical chemistry analyzers
Probe/cuvette wash supply and waste removal
Bubble and pressure detection in clinical chemistry analyzers
Tubing and fittings in clinical chemistry analyzers
Multiport rotary valves in clinical chemistry analyzers
Sample, reagent and wash-path switching
Piston pumps in clinical chemistry analyzers
Metered reagent dispensingSample aspiration and transfer
Sampling and wash probes in clinical chemistry analyzers
Syringe pumps in clinical chemistry analyzers

On this page

What do these products do in this instrument?Match component geometry to actual containersEvaluate interfaces by receiving or cleaning resultsTranslate actual branch conditions into configuration requirementsCompare product configurations by the roles on this pageRelated operations and architecture comparisonsConfirm product roles in actual operationCan sampling and wash probes be replaced based on similar appearance alone?ReferencesRelated guides

01What do these products do in this instrument?

Sampling probes: container-side sampling and delivery

Form aspiration and delivery interfaces between sample containers and reaction cuvettes, coordinated with pump displacement, liquid level and motion. Evaluate probe-tip position, droplets and sampling with low remaining liquid in the source container together with cleaning.

Custom sampling probes connect source containers to receiving positions. Diameter, tip, surface and interface depend on sample and container. Tip geometry must work with metering drive and motion sequences.

Wash probes: cleaning coverage and residual-liquid removal

Direct wash fluid to contaminated surfaces at probe or cuvette washing stations and aspirate residual liquid where supported. Coordinate supply and aspiration, checking height against actual cuvette geometry and recovery for the next reaction.

Custom wash probes form the container interface for wash-fluid entry or residual-liquid extraction. Confirm supply coverage, aspiration height and drainage timing together with actual container shape.

02Match component geometry to actual containers

Sampling and wash probes must fit container openings, bottoms, minimum levels and motion strokes. Record actual contact surfaces and permitted positions before defining tips, interfaces and motion space; appearance alone is insufficient for selection.

Further technical reading

  • Piston Pump Accuracy, Repeatability and Resolution Explained
  • What Are Cleaning, Wash and Rinse Pumps in IVD Systems, and Why Are Miniature Diaphragm Pumps Used?
  • Why do multiple wash nozzles deliver different flows from one miniature diaphragm pump?

03Evaluate interfaces by receiving or cleaning results

At the source, check reachable positions and low remaining volume; at the receiver, check actual volume, droplets or permitted residue. Test wetted-surface maintenance and recovery for the next container during consecutive operation. Reconfirm position and delivery after changing probes, tubing length or containers.

04Translate actual branch conditions into configuration requirements

Sampling- and wash-probe configuration conditions in clinical chemistry analyzers
ConditionTo confirm
Container and positionProvide opening, bottom, minimum level, positioning error and available motion space.
Liquid contact and surfacesSpecify sample or reagent, residue requirements and internal/external probe cleaning.
Actual functionCheck delivery, coverage, residue, solid-phase retention or mixing results according to the task.
Operations supported in this instrument
OperationSpecific operating conditions
Sample aspiration and transferActual sample volume, remaining source volume, probe-tip height, aspiration/dispensing speed and system liquid
Metered reagent dispensingDose per operation, total cycle volume, replenishment/bottle-change interval, backpressure and receiving geometry
Probe/cuvette wash supply and waste removalWash-fluid formulation, volume/time, spray/aspiration geometry, air/foam and waste capacity

05Compare product configurations by the roles on this page

Configuration options for the product roles on this page
ProductConfiguration optionConditions to verify
Custom sampling probeSampling interface between source container and fluidic pathCompare custom geometry by minimum liquid level, probe-tip clearance and actual sample
Custom wash probeWashing interface for probe interiors/exteriors or containersConfirm contaminated surfaces, coverage, aspiration height and peak waste removal
  • Custom sampling probe

    Custom sampling probe

    View Details
  • Custom wash probe

    Custom wash probe

    View Details

06Related operations and architecture comparisons

Sample aspiration and transfer

Low remaining volume, probe contact with a wall and aspiration/dispensing reversals may alter delivery. First measure error in the target container, then assess residue using a blank after a concentrated sample; one calibration cannot address both issues.

  • Sample aspiration and transfer

Metered reagent dispensing

For repeated dispensing, record usable doses per fill and replenishment points. Confirm restoration of the liquid column after replenishment before evaluating the first dose. Retrying an interrupted action must also avoid duplicate addition to the same cuvette.

  • Metered reagent dispensing

Probe/cuvette wash supply and waste removal

Internal-probe, external-probe and cuvette-bottom residue cannot all be solved by increasing the same supply volume. Check cleaning coverage, aspiration height and waste capacity, then validate recovery with high/low concentration switching and blanks.

  • Probe/cuvette wash supply and waste removal

07Confirm product roles in actual operation

Operating-point validation and fault localization
OperationMeasurements and observationsPriority checks
Sample aspiration and transferMeasure actual delivery at the receiver, covering routine small volumes and maximum task volume, first dose after idle, sample changes and high/low concentration sequencesAir aspiration, clots/particles, probe contact with a wall or leakage alter actual delivery
Metered reagent dispensingUse actual media to check first, middle and last doses and delivery after bottle changes; confirm received volume and timing rather than substituting commanded steps for volumeEmpty sources, bubbles, nozzle droplets and backpressure changes affect first or last doses
Probe/cuvette wash supply and waste removalConfirm supply and peak waste-removal capacity under installed resistance; measure residual liquid, carryover or assay-specified recoveryInsufficient supply, foam, dry aspiration and a full waste container disrupt the cleaning cycle

Check delivered volume, first dose after idle and residue after high/low concentration switching at the receiving location.

08Can sampling and wash probes be replaced based on similar appearance alone?

Confirm tip, channels, interfaces and operating positions separately, then validate each probe's aspiration/dispensing or cleaning results. Similar appearance does not imply equal wetted volume, coverage or residual-liquid levels.

The assay determines sample suitability; full-scale metering specifications cannot replace small-dose and complete-instrument results.

References

View references (2)
  1. [1]FOREACH custom sampling probes: configurations and specifications
  2. [2]FOREACH custom wash probes: configurations and specifications

Related guides

  • Back to the clinical chemistry analyzer fluidics overview

Related Products

Sampling probes

Sampling probes

Wash probes

Wash probes

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What Are Cleaning, Wash and Rinse Pumps in IVD Systems, and Why Are Miniature Diaphragm Pumps Used?

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Discuss Your IVD Fluidic Requirements

Share the instrument type, sample and reagent properties, working volumes, cycle timing, fluid path and acceptance criteria so we can discuss suitable components and prototype evaluation.

Discuss your application