What do these products do in this instrument?
Syringe Pumps: Discrete Dispensing by Well or Well Group
Supply specified doses at metered plate stations in coordination with valves, dispensing heads and well order. Evaluate first and last wells, different channels and the first dose after replenishment separately.
HLD and HMD organize aspiration/dispensing paths with rotary and solenoid valves respectively. Capacity budgets include useful volume, holding stages and replenishment points; valve states and pump actions together create each delivery.
Organize syringe metering around aspiration, holding and dispensing
Syringe drives use controlled displacement for aspiration, holding and dispensing. With direct contact, source liquid enters the metering chamber; with system-liquid drive, sample can remain at the probe tip or a designated tube segment. Define wetted coverage before capacity, cleaning and replenishment. For repeated dispensing, track current inventory, delivered volume and next replenishment time.
Map valve connections to every action
Check port connections, opening/closing sequence and power-off state separately for rotary- and solenoid-valve configurations. Changing source does not automatically remove old liquid from the chamber or shared tubing. Plan flushing for formulation and residue requirements, then evaluate the first dose after switching and dose-to-dose variation.
Translate actual branch conditions into configuration requirements
| Condition | To confirm |
|---|---|
| Stored volume and timing | Define volume per operation, consecutive dispensing count, holding time and permitted replenishment window. |
| Valve positions and destinations | Provide a source, receiver and waste port diagram with open/closed and power-off states. |
| Liquid changes and first dose | Check shared residue, priming destination and actual received volume after standby or source changes. |
| Operation | Specific operating conditions |
|---|---|
| Well dispensing | Plate format, well positions, independent channels, branch resistance and concurrent flow |
Compare product configurations by the roles on this page
| Product | Configuration option | Conditions to verify |
|---|---|---|
| HLD rotary-valve syringe pump | Aspiration, holding and dispensing with a rotary valve | Check source/outlet valve positions, capacity budget and replenishment timing |
| HMD solenoid-valve syringe pump | Metered aspiration and dispensing with solenoid valves | Check open/closed and power-off states, working volume and replenishment cycle |
Explore specific operating and validation tasks
Well dispensing
Include first, last and edge wells and concurrent operations. Record branch lengths and receiving heights. The port count of a multiport selector valve does not equal the number of simultaneous supply channels.
Confirm product roles in actual operation
| Operation | Measurements and observations | Priority checks |
|---|---|---|
| Well dispensing | Measure first and last wells, channel differences and the complete plate cycle; preserve well identities and verify actual delivery and residual liquid. | Empty sources, bubbles, nozzle droplets and backpressure changes affect first or last doses |
Assess differences in delivered volume between wells, residual liquid after washing and the complete plate cycle. Preserve well identities.
For repeated dispensing from one chamber, is checking total volume enough?
Measure each received dose, especially the first and last. Even when total volume is near target, individual errors may differ. Relate replenishment, valve switching and receiving actions to each result.
Multiport selection does not provide independent simultaneous channels. Validate washing through both liquid handling and retention of the required solid phase.