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Valveless-pump titration: when to use bulk addition and when fine metering is needed

Application guide

Titration changes addition according to the response. A suitable valveless pump can be considered for titrant delivery, but increments and stop behavior near the endpoint require independent testing; nominal displacement does not establish them.

Application guides

Analytical instruments

Analytical instruments Overview
Liquid chromatography systems: locate the fluidic task before selecting pumps and valves
Spectroscopy and elemental analysis
Water analysis units
Analytical Sample Preparation
Analytical system integration
Piston Pumps in Analytical Instruments
Automated dilution with piston pumpsPiston Pump Titration
Syringe pump
Syringe-pump samplingMultiple dispensing with syringe pumpsSyringe-pump standard preparation and over-range sample dilutionSequential injection and flow analysis
Air-displacement pipetting pump
Disposable-Tip Sample TransferTip-based dilution and dispensingTip-based sample preparation
Valveless metering pumps
Repeated Dispensing with Valveless PumpsValveless-pump titrationCarrier-liquid and flow-cell supplyTwo-stream proportioning
Diaphragm pump
Wash-liquid supply and primingWorking-liquid replenishmentAuxiliary liquid circulationGas-liquid waste aspiration
Valves for Analytical Fluidics
MRV3 multi-source selectionHigh-pressure sample-loop injectionDetector Flow Diversion and BypassSolenoid-valve shutoff
Sampling, Washing and Mixing Components
Sampling needlesProbe-wash stationReaction-cup and microplate washingReaction mixing
Fluidic monitoring
Bubble and Liquid-State DetectionPressure and Blockage Monitoring
Tubing, fittings, filters and check valves
Tubing materials and dimensionsLow-retention connectionsFiltration and backflow protection

ON THIS PAGE

Locate the source, drive and receiving position for this taskAssess architecture suitability from the required endpoint incrementCompare product options against task requirementsControl stopping, residual droplets and mixing delaysLink actual increments to endpoint validationAfter an abnormality or maintenance, first identify which segment needs recoveryContinue with tasks on the same branchReferencesRelated guides

01Locate the source, drive and receiving position for this task

Titrant→Valveless delivery and stopping→Reaction mixing→Endpoint detection
Functional or operational sequence; confirm connections and branches for each state on the instrument

Required inputs are expected total consumption, bulk-addition speed, effective increments near the endpoint, residual drips and signal stabilization time. Confirm liquid contact, pressure and destination along each illustrated section before defining drive and connection responsibilities.

02Assess architecture suitability from the required endpoint increment

Define total consumption, bulk-addition rate and allowable increments near the endpoint. If the required effective increment is outside the validated range, compare architectures better suited to fine metering.

Compare configuration conditions by actual task
Condition to compareInformation requiredSelection affected
Bulk-addition rangeExpected consumption and available timeAssess suitability for bulk addition
Endpoint incrementActual minimum increment and post-stop residual liquidDetermine whether fine increments require another configuration
Signal timingMixing, reaction and detection waiting timesDistinguish the stop command from endpoint detection

03Compare product options against task requirements

The following candidate options match this page's responsibilities. Compare them against the operating conditions described, then check capacity, materials and interfaces on the product pages. Card images show representative configurations; suitability must still be confirmed at actual operating points and by application results.

Move from task conditions to product configuration
Product categoryCorresponding roleConfirm before selection
RPL Valveless Metering PumpSuitable repeated or continuous meteringCompare displacement, speed, actual backpressure and starts/stops; check two-stream ratios separately
EA standard piston pumpFinite-stroke meteringCompare configurations by routine dose, total cycle displacement and wetted materials
  • RPL Valveless Metering Pump
  • EA standard piston pump

04Control stopping, residual droplets and mixing delays

Relate addition, mixing waits and detection response. Post-stop drips, tubing elasticity and delivery delay can cause endpoint overshoot. The control program must retain cumulative delivered volume.

Action records should link commands, valve or interface states and actual received results. When raw material, container or sample identity changes, reconfirm shared paths and conditions permitting the next step. Completion of drive movement alone does not replace task acceptance.

05Link actual increments to endpoint validation

Measure actual incremental and cumulative volume, then validate the endpoint against method-specified standards. Diagnose pump output, mixing, response delay and algorithms separately rather than attributing every endpoint fault to insufficient capacity.

Link operating-point tests to interpretable results
Validation scenarioMeasurement or observationInterpretation and action
Volume added after stoppingMeasure post-stop droplets and small incrementsAssess near-endpoint capability using actual received volume
Complete titrationUse standards to assess bulk addition, fine increments and waiting periodsValidate endpoint results before deciding architecture suitability

Record test medium, configuration, installed path and operating sequence; present routine operating points and boundary results separately. Calculations support design discussions, component documentation checks models, and installed measurements confirm the actual task.

06After an abnormality or maintenance, first identify which segment needs recovery

Retained droplets, oversized increments, insufficient mixing or an unstable signal may cause endpoint overshoot. Check results from the affected step before resuming.

Retain current source, container identity, completed actions, valve or interface state and actual receiving information. Use the table to locate the stage that changed before deciding to retry, continue or restart. After recovery, recheck the relevant operating point before returning an uncertain action to the automatic cycle.

  • Bring the fluidic diagram and operating-point records to discuss configuration

07Continue with tasks on the same branch

  • Valveless metering pumps: operating conditions for repeated dispensing and continuous supply
  • Repeated Dispensing with Valveless Pumps: Displacement, Start-Stop Behavior and Nozzle Droplets
  • Carrier and Flow-Cell Supply: Installed Flow, Bubbles and Baseline
  • Dual-Stream Proportioning: Cumulative Ratio and Instantaneous Mixing

References

View references (2)
  1. [1]Fluid Metering: Valveless Metering and Dispensing Pump Collection
  2. [2]FOREACH: Valveless Metering Pump Product Range

Related guides

  • Piston Pump Titration: Separate Endpoint Increments from Bulk Addition
  • Reaction mixing: geometry, speed and reaction uniformity
  • Pressure and blockage monitoring: establish action baselines before fault thresholds

Related Products

RPL Valveless Metering Pump; representative configuration. Select capacity, materials and interfaces for the application.

RPL Valveless Metering Pump

EA standard piston pump; representative configuration. Select capacity, materials and interfaces for the application.

EA standard piston pump

Related Technical Articles

Valveless Metering Pump Selection Guide: FOREACH Models and Applications

To select a valveless metering pump, first define the volume per dose and the time available for dispensing. Then check displacement per revolution, drive speed, wetted materials, backpressure and connections, and verify delivery in the actual fluid path. Neither flow rate alone nor the label ‘metering pump’ is enough to select a model.

2026-09-16View Details

Piston Pump Accuracy, Repeatability and Resolution Explained

Learn why theoretical volume per step is not the minimum reliable dose, and how accuracy, repeatability, valves, bubbles and working stroke affect dispensing results.

2026-09-06View Details

Discuss your valveless-pump titration fluidics

Provide a fluid diagram, the actual liquids and pressures in each state. Specify expected consumption and available time; actual minimum increment and post-stop residual liquid; and waits for mixing, reaction and detection. Compare suitable configurations against the validation objectives described here.

Contact an engineer