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Sampling, washing and mixing components: define interfaces from vessel geometry

Application guide

Probes, wash heads and mixing components form the interface between liquid delivery and vessels. Their geometry, position and wetted surfaces affect sampling, retained droplets, residual liquid and mixing. Pump output does not replace interface design.

Application guides

Analytical instruments

Analytical instruments Overview
Liquid chromatography systems: locate the fluidic task before selecting pumps and valves
Spectroscopy and elemental analysis
Water analysis units
Analytical Sample Preparation
Analytical system integration
Piston Pumps in Analytical Instruments
Automated dilution with piston pumpsPiston Pump Titration
Syringe pump
Syringe-pump samplingMultiple dispensing with syringe pumpsSyringe-pump standard preparation and over-range sample dilutionSequential injection and flow analysis
Air-displacement pipetting pump
Disposable-Tip Sample TransferTip-based dilution and dispensingTip-based sample preparation
Valveless metering pumps
Repeated Dispensing with Valveless PumpsValveless-pump titrationCarrier-liquid and flow-cell supplyTwo-stream proportioning
Diaphragm pump
Wash-liquid supply and primingWorking-liquid replenishmentAuxiliary liquid circulationGas-liquid waste aspiration
Valves for Analytical Fluidics
MRV3 multi-source selectionHigh-pressure sample-loop injectionDetector Flow Diversion and BypassSolenoid-valve shutoff
Sampling, Washing and Mixing Components
Sampling needlesProbe-wash stationReaction-cup and microplate washingReaction mixing
Fluidic monitoring
Bubble and Liquid-State DetectionPressure and Blockage Monitoring
Tubing, fittings, filters and check valves
Tubing materials and dimensionsLow-retention connectionsFiltration and backflow protection

ON THIS PAGE

Locate the source, drive and receiving position for this taskDefine probe and mixing interfaces from vessel geometryCompare product options against task requirementsConfirm position before liquid motionCheck delivery and residue in actual vesselsAfter an abnormality or maintenance, first identify which segment needs recoveryContinue with tasks on the same branchReferencesRelated guides

01Locate the source, drive and receiving position for this task

Source or wash liquid→Needle, wash head or mixing element→Target-vessel interface→Washing and drainage
Functional or operational sequence; confirm connections and branches for each state on the instrument

Specify vessel opening and bottom geometry, minimum liquid level, positioning accuracy and sampling, washing or mixing targets. Trace contact surfaces, pressure and destinations along the diagram before assigning pump and connection roles.

02Define probe and mixing interfaces from vessel geometry

Specify the vessel, minimum liquid level, target dose, bottom clearance and wash coverage before selecting a design. Mixing components also require speed, immersion, foaming and reaction requirements.

Compare configuration conditions by actual task
Condition to compareInformation requiredSelection affected
Container geometryOpening, bottom, liquid level and accessible positionsDefine length, shape and motion range
Task categorySampling, internal/external washing or reaction mixingSeparate interface and action requirements
Contamination pathsContact surfaces, shared sections and wash areasDefine coverage and readiness for the next vessel

03Compare product options against task requirements

The following candidate options match this page's responsibilities. Compare them against the operating conditions described, then check capacity, materials and interfaces on the product pages. Card images show representative configurations; suitability must still be confirmed at actual operating points and by application results.

Move from task conditions to product configuration
Product categoryCorresponding roleConfirm before selection
Custom sampling probeSampling interface between source container and fluidic pathCompare custom geometry by minimum liquid level, probe-tip clearance and actual sample
Custom wash probeWashing interface for probe interiors/exteriors or containersConfirm contaminated surfaces, coverage, aspiration height and peak waste removal
Custom mixing paddleReaction mixing inside the containerCompare geometry and motion through uniformity, foam and method response
  • Custom sampling probe
  • Custom wash probe
  • Custom mixing paddle

04Confirm position before liquid motion

Combine position confirmation, liquid operations and washing into a cycle. Needle interiors/exteriors and vessel walls/bottoms have different contaminated surfaces. Set aspiration height separately for supernatant or solid-phase tasks.

Action records should link commands, valve or interface states and actual received results. When raw material, container or sample identity changes, reconfirm shared paths and conditions permitting the next step. Completion of drive movement alone does not replace task acceptance.

05Check delivery and residue in actual vessels

Check delivery, residual liquid, coverage and method results in the actual container. Select high/low-concentration sequences, recovery or mixing-uniformity tests for the specific task.

Link operating-point tests to interpretable results
Validation scenarioMeasurement or observationInterpretation and action
Task outcomesMeasure delivery, residual liquid or mixing uniformity separatelyAssess components against their actual task
Complete cycleInclude vessel changes, washing and maintenanceA successful single action does not establish contamination control across a batch

Record test medium, configuration, installed path and operating sequence; present routine operating points and boundary results separately. Calculations support design discussions, component documentation checks models, and installed measurements confirm the actual task.

06After an abnormality or maintenance, first identify which segment needs recovery

Geometry mismatch, position error or surface residue can affect liquid handling. Check actual results from the affected step before resuming the next action.

Retain current source, container identity, completed actions, valve or interface state and actual receiving information. Use the table to locate the stage that changed before deciding to retry, continue or restart. After recovery, recheck the relevant operating point before returning an uncertain action to the automatic cycle.

  • Bring the fluidic diagram and operating-point records to discuss configuration

07Continue with tasks on the same branch

  • Sampling Probes: Liquid Level, Bottom Clearance and Tip Delivery
  • Probe Wash Stations: Identifying Contaminated Surfaces and Validating Blank Recovery
  • Cuvette and Microplate Washing: Residue, Solid Phase and Head Position
  • Reaction mixing: geometry, speed and reaction uniformity

References

View references (2)
  1. [1]Roche: cobas c 311 Operator's Manual — Sample Probe Wash and Clog Recovery
  2. [2]FOREACH: Sampling and Wash Probe Product Range

Related guides

  • Sampling Probes: Liquid Level, Bottom Clearance and Tip Delivery
  • Probe Wash Stations: Identifying Contaminated Surfaces and Validating Blank Recovery
  • Cuvette and Microplate Washing: Residue, Solid Phase and Head Position
  • Reaction mixing: geometry, speed and reaction uniformity

Related Products

Custom sampling probe; representative configuration. Select capacity, materials and interfaces for the application.

Custom sampling probe

Custom wash probe; representative configuration. Select capacity, materials and interfaces for the application.

Custom wash probe

Custom mixing paddle; representative configuration. Select capacity, materials and interfaces for the application.

Custom mixing paddle

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Discuss fluidics for your sampling, washing and mixing components

Provide a fluid diagram, the actual liquids and pressures in each state. Specify vessel openings, bottoms, liquid levels and accessible positions; sampling, internal/external washing or reaction mixing; and contact surfaces, shared sections and wash areas. Compare suitable configurations against the validation objectives described here.

Contact an engineer