Foreach TechnologyForeach Technology
Home
Products
Applications
About Us
Contact & Partnership
简体中文EnglishEspañolFrançais한국어Русский
Home
Products
Pump SeriesValve SeriesTubing SeriesFitting SeriesProbe SeriesSmart Control SeriesTubing Assemblies
Applications
All applicationsIVD DiagnosticsLife SciencesLaboratory AutomationAnalytical InstrumentsEnvironmental MonitoringSynthetic Biology
Resources
DatasheetsFluid Resistance CalculatorFitting ReplacementInstallation GuidesMaterial CompatibilityTechnical ArticlesCompany News
About Us
About ForeachR&D and ManufacturingQuality System and QualificationsMilestonesForeach Culture
Contact & Partnership
Contact UsBecome a Distributor
  • Pump Series
  • Valve Series
  • Probe Series
  • Fitting Series
  • Tubing Series
  • Control Series
  • Tubing Assemblies
  • All applications
  • IVD
  • Life Science
  • Lab Automation
  • Analytical Instruments
  • Environmental Monitoring
  • Synthetic Biology
  • Datasheets
  • Fluid Resistance Calculator
  • Fitting Replacement
  • Installation Guides
  • Material Compatibility
  • Technical Articles
  • Company News
  • About Foreach
  • R&D & Manufacturing
  • Quality & Compliance
  • History
  • Foreach Culture
  • Inquiry Form
  • Contact Information

Shenzhen Foreach Technology Co., Ltd.

Address: 13th Floor, 2nd Building, Yufengda Industrial Park, 1008th Guang Qiao Boulevard, Guangming District, Shenzhen 518132 CHINAView Map

Email: [email protected]

Tel: +86 755 8655 3831

LinkedInYouTubeFacebookInstagramX

© 2026 Shenzhen Foreach Technology Co., Ltd. All rights reserved.

Privacy Policy·

Home/Applications/Analytical instruments
< Back

Low-Hold-Up Connections: Matching Threads, Tube Ends and Port Geometry

Application guide

Connection quality depends on threads, sealing design, tube-end positioning and port geometry together. Matching thread sizes do not imply identical wetted geometry. Gaps can trap liquid and incorrect assembly can leak.

Application guides

Analytical instruments

Analytical instruments Overview
Liquid chromatography systems: locate the fluidic task before selecting pumps and valves
Spectroscopy and elemental analysis
Water analysis units
Analytical Sample Preparation
Analytical system integration
Piston Pumps in Analytical Instruments
Automated dilution with piston pumpsPiston Pump Titration
Syringe pump
Syringe-pump samplingMultiple dispensing with syringe pumpsSyringe-pump standard preparation and over-range sample dilutionSequential injection and flow analysis
Air-displacement pipetting pump
Disposable-Tip Sample TransferTip-based dilution and dispensingTip-based sample preparation
Valveless metering pumps
Repeated Dispensing with Valveless PumpsValveless-pump titrationCarrier-liquid and flow-cell supplyTwo-stream proportioning
Diaphragm pump
Wash-liquid supply and primingWorking-liquid replenishmentAuxiliary liquid circulationGas-liquid waste aspiration
Valves for Analytical Fluidics
MRV3 multi-source selectionHigh-pressure sample-loop injectionDetector Flow Diversion and BypassSolenoid-valve shutoff
Sampling, Washing and Mixing Components
Sampling needlesProbe-wash stationReaction-cup and microplate washingReaction mixing
Fluidic monitoring
Bubble and Liquid-State DetectionPressure and Blockage Monitoring
Tubing, fittings, filters and check valves
Tubing materials and dimensionsLow-retention connectionsFiltration and backflow protection

ON THIS PAGE

Locate the source, drive and receiving position for this taskMatch the tube end to the port geometryCompare product options against task requirementsAssemble for the specific design and check sealingConfirm connections through pressure cycles and method resultsAfter an abnormality or maintenance, first identify which segment needs recoveryContinue with tasks on the same branchReferencesRelated guides

01Locate the source, drive and receiving position for this task

Upstream liquid→Tube-end positioning and fitting seal→Port-bottom geometry→Downstream path
Functional or operational sequence; confirm connections and branches for each state on the instrument

Define tubing ID/OD, length, interface geometry, pressure, materials and maintenance method. Follow the diagram to confirm liquid contact, pressure and destination before assigning drive and connection roles.

02Match the tube end to the port geometry

Provide a port drawing, tubing material and OD, pressure and disassembly frequency. For low-volume work, calculate the actual gap between the tube end and port bottom rather than relying on a fitting's nominal description.

Compare configuration conditions by actual task
Condition to compareInformation requiredSelection affected
Threads and sealingPort drawing, sealing method and matching componentsMatching threads do not establish interchangeability
Tubing-end positionTube material, outside diameter, cut end and insertion depthMinimize gaps and maintain the intended wetted connection
Repeated maintenanceDisassembly frequency and actual pressure cyclesCheck tightening method and service-life requirements

03Compare product options against task requirements

The following candidate options match this page's responsibilities. Compare them against the operating conditions described, then check capacity, materials and interfaces on the product pages. Card images show representative configurations; suitability must still be confirmed at actual operating points and by application results.

Move from task conditions to product configuration
Product categoryCorresponding roleConfirm before selection
Rigid-tubing fittingsTube-end positioning and sealed connectionsCheck tube outer diameter, threads, seal structure and port-bottom geometry
  • Rigid-tubing fittings

04Assemble for the specific design and check sealing

Cut, position and tighten tubing according to the appropriate assembly method, checking direction and tube-end condition. Recheck sealing and volume after repeated maintenance. Additional tightening force does not solve every problem.

Action records should link commands, valve or interface states and actual received results. When raw material, container or sample identity changes, reconfirm shared paths and conditions permitting the next step. Completion of drive movement alone does not replace task acceptance.

05Confirm connections through pressure cycles and method results

Test leakage, pressure cycling and shared-path recovery, adding peak-shape or recovery checks where the method requires them. Assembly is only the starting point; acceptance depends on operating performance.

Link operating-point tests to interpretable results
Validation scenarioMeasurement or observationInterpretation and action
Sealing during operationCheck leakage at actual pressure and recovery after disassemblyDo not compensate for incompatible interfaces with increasing tightening force
Volume and residueCheck delay, blanks or peak shape after connectionRecheck shared-path behavior after assembly changes

Record test medium, configuration, installed path and operating sequence; present routine operating points and boundary results separately. Calculations support design discussions, component documentation checks models, and installed measurements confirm the actual task.

06After an abnormality or maintenance, first identify which segment needs recovery

Misconnections, gaps, tube deformation or leaks may alter volume and pressure. Isolate the affected segment and reconfirm assembly; matching threads do not establish interchangeability.

Retain current source, container identity, completed actions, valve or interface state and actual receiving information. Use the table to locate the stage that changed before deciding to retry, continue or restart. After recovery, recheck the relevant operating point before returning an uncertain action to the automatic cycle.

  • Bring the fluidic diagram and operating-point records to discuss configuration

07Continue with tasks on the same branch

  • Tubing, Fittings, Filters and Check Valves: Assess the Complete Flow Path
  • Tubing Materials and Dimensions: Volume, Resistance and Maintenance Layout
  • Filter and check-valve protection: analytes, resistance and maintenance limits

References

View references (2)
  1. [1]IDEX Health & Science: Fluidics FAQs — Dead Volume and Fittings
  2. [2]FOREACH: Fittings and Tubing Catalog

Related guides

  • Tubing Materials and Dimensions: Volume, Resistance and Maintenance Layout
  • High-Pressure Sample-Loop Injection: Loading and Injection States
  • Filter and check-valve protection: analytes, resistance and maintenance limits

Related Products

Rigid-tubing fittings; representative configuration. Select capacity, materials and interfaces for the application.

Rigid-tubing fittings

Related Technical Articles

What is flow resistance calculation for? Using the Foreach calculator in fluid-path design and selection

The free flow rate of the pump meets the requirements. After installing the pipelines, valves and joints, the liquid supply at the end is insufficient. Flow resistance calculations can break the problem down into comparable data: what pressure differential is required at the target flow rate, where does the pressure loss mainly occur, and what happens if the pipe diameter, pipe length, component Cv or medium viscosity is changed. This article combines the actual function of the Foreach flow resistance calculator with a recalculable fluid circuit case to explain how to use the calculation results for design, selection, troubleshooting and prototype verification.

2026-09-11View Details

How Does a 6-Port HPLC Injection Valve Work? Load, Inject and Vent

Follow sample loading into an external loop and transfer to the column by the mobile phase, distinguishing the HP valve's main positions and vent path from the factors that determine injection volume.

2026-09-29View Details

Discuss Your Low-Hold-Up Connections

Provide a fluidic diagram, actual liquids and pressures in each operating state. Specify port drawings, sealing method and mating components; tubing material, OD, cut and insertion depth; and disassembly frequency and actual pressure cycles. Compare configurations against this guide's validation objectives.

Contact an engineer